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HESS Provides Superior Accuracy over LDSC in Estimating Local Heritability
HESS attains unbiased estimates when in-sample LD is used (top) and approximately unbiased estimates when reference LD is used (bottom). The mean and SE in these figures were computed on the basis of 500 simulations, each involving 50,000 simulated GWAS datasets. Error bars represent twice the SE.
