Figure 1.

Pedigree Structure Used to Simulate Ninth-Degree Pedigrees

100 ninth-degree pedigrees, each with different genotypes, were generated with A2 and B2 related as ninth-degree relatives. The same pedigree structures for samples A1–A13 and B1–B13 were also used to generate 100 pedigrees, each with different genotypes, where A2 and B2 were fourth-, fifth-, sixth-, seventh-, eighth-, and ninth-degree relatives. The number of ancestral relatives was adjusted to account for the different degree of relatedness.