Figure 6.

CDC45 Protein Levels Are Significantly Reduced in Lymphoblastoid Cell Lines and Primary Amniocytes

Cell lines from affected individuals (P1, P2, P9-1) and amniocytes derived from affected fetuses (P12-1 and P12-2) demonstrate a significant reduction in endogenous CDC45 levels compared to three independent controls (LCL samples: one-way ANOVA comparing all LCL samples against C1; error bars indicate standard deviation; NS, p > 0.01, ^∗∗∗∗p < 0.0001, n = 5 biological replicates; amniocyte samples: one-way ANOVA comparing all amniocyte samples against C4. ^∗∗∗p < 0.001, ^∗∗∗∗p < 0.0001, n = 3 biological replicates).