Table II.
The top three gene modules identified for rheumatoid arthritis peripheral blood mononuclear cells
| Module name | Gene | GWAS meta-analysis p-value |
|---|---|---|
| GRB7 | HLA-DRB5 | 3.51E−235 |
| HLA-DRA | 1.00E−285 | |
| KIT | 2.65E−03 | |
| GRB7 | 7.70E−01 | |
| CD63 | 7.00E−02 | |
| MAP4K5 | HLA-DQA2 | 4.08E−285 |
| HLA-DQB1 | 4.08E−285 | |
| PIK3R1 | 1.72E−03 | |
| CRKL | 1.30E−01 | |
| CD4 | 6.00E−02 | |
| CD3E | 5.00E−02 | |
| MAP4K5 | 7.00E−02 | |
| VAV3 | 1.00E−02 | |
| IL1R1 | 5.05E−03 | |
| ZFP36L1 | PTPN22 | 7.36E−27 |
| EGFR | 1.94E−04 | |
| NRG1 | 2.61E−03 | |
| ITGA5 | 3.31E−03 | |
| ZFP36L1 | 4.45E−03 | |
| PTPRE | 1.00E−02 | |
| GRB2 | 2.00E−02 | |
| MAPK14 | 3.00E−02 |
GWAS, genome-wide association study