Figure 11.

Human AD-TBS induces microglial inflammatory mRNA profile shift in SH mice as shown by Nanostring mRNA counts, and EE rescues such shift. A, At 48 h, 31 genes are significantly altered by oAβ in SH mice (uncorrected). The genes are assigned to each panel according to exact mRNA counts from Nanostring, which reflects expression level. N = 6. B, At 48 h, 24 of 31 genes plotted in A are rescued by EE. Total mRNA counts for the 24 genes show no significant difference between EE mice receiving AD-TBS and receiving ID-ADTBS. N = 6. Quantitative data are mean ± SEM.