Table 1.

Maximal responses, pD₂ values, and area under the curve of endothelium-dependent relaxations to acetylcholine. Responses were determined in the presence of the TP receptor antagonist SQ 29,548 (1 μmol/L). Values were calculated by fitting of concentration-response curves (DeLean et al. 1978). Area under the curve is expressed as arbitrary units. All data (n = 4–5 per group) are mean ± sem

	Young	Aged	p value
Maximal responses (% PE)	−98 ± 1	−98 ± 1	1.0
pD2 values (−log mol/L)	8.3 ± 0.1	7.8 ± 0.1	0.01
Area under the curve (AU)	318 ± 8	275 ± 14	0.04

PE phenylephrine, AU arbitrary units