Table 2.
Selected biochemical markers in the centenarian group (n = 43) and the quinquagenarian control group (n = 30)
| Measure | Centenarian group | Quinquagenarian control group n = 30 |
Centenarians vs quinquagenarians P value |
|||
|---|---|---|---|---|---|---|
| All subjects n = 43 |
Survivors n = 28 |
Non-survivors n = 15 |
Survivors vs non-survivors P value |
|||
| Age, years | 101.1 ± 1.0 | 100.9 ± 0.7 | 101.4 ± 1.3 | .457 | 51.8 ± 5.0 | <.001 |
| sP-selectin, ng/mL | 77.9 ± 86.5 | 84.0 ± 102.7 | 67.9 ± 49.9 | .497 | 35.7 ± 17.4 | <.001 |
| sICAM-1, ng/mL | 258 ± 114 | 257 ± 83 | 261 ± 154 | .652 | 166 ± 77 | <.001 |
| sVCAM-1, ng/mL | 689 ± 251 | 660 ± 218 | 737 ± 296 | .373 | 428 ± 109 | <.001 |
| sCD40-L, pg/mL | 795 ± 2330 | 906 ± 2880 | 672 ± 1110 | .246 | 1690 ± 4649 | .010 |
| IL-6, pg/mL | 5.92 ± 3.41 | 4.84 ± 3.41 | 7.87 ± 2.47 | .003 | 1.03 ± 0.65 | <.001 |
| ET-1, pg/mL | 1.03 ± 0.32 | 0.95 ± 0.29 | 1.19 ± 0.33 | .005 | 0.92 ± 0.34 | .150 |
| TNF-α, pg/mL | 4.13 ± 6.09 | 3.44 ± 4.65 | 5.39 ± 8.11 | .407 | 1.00 ± 0.31 | <.001 |
| PAI-1, ng/mL | 15.5 ± 5.0 | 19.4 ± 61.8 | 8.1 ± 5.9 | .949 | 37.6 ± 72.4 | .006 |
| MMP-1, ng/mL | 12.7 ± 49.5 | 15.7 ± 61.0 | 6.9 ± 1.3 | .532 | 1.9 ± 49.6 | <.001 |
| TIMP-1, ng/mL | 504 ± 166 | 485 ± 177 | 540 ± 141 | .198 | 183 ± 74 | <.001 |
| MMP-9, ng/mL | 1192 ± 762 | 1164 ± 737 | 1246 ± 830 | .769 | 159 ± 96 | <.001 |