Fig. 2.

Performance of the SAMP8 mice in the MWM. The old controls exhibited a significantly lower swimming velocity (a) and longer distance (b) than the young mice in the place-learning phase and a lower percentage of distance (c) than the young mice in the target quadrant in the probe trial. Both the HD-DNJ and the LD-DNJ mice had shorter distances than the O-con (b). The HD-DNJ mice, but not the LD-DNJ mice, showed a higher percentage of distance (c) than the O-con. The bars represent SEM. *P < 0.05 denotes significant DNJ effect. #P < 0.05 denotes significant age effect