Fig. 8.

Effect of age or DNJ on GFAP immunohistochemical staining in the dorsal hippocampus. Representative high-magnification (×20) photos in the hippocampal subregions (DG, CA1, and CA3) in each group are shown. The old SAMP8 mice showed a higher GFAP immunoreactivity in the subregions. The GFAP-positive astrocytes in the old hippocampus were morphologically hypertrophic with enlarged processes, indicating activation of the astrocytes. DNJ treatment significantly relieved the astrocyte activation. DG dentate gyrus. Scale bar = 100 μm