Table 1.
Performance of the SAMP8 mice in the sensorimotor task and locomotor- and anxiety-based tasks
| Tasks | Parameters | Old control | Young control | HD-DNJ group | LD-DNJ group |
|---|---|---|---|---|---|
| Beam walking | Balance time (s) | 91.5 ± 10.2 | 136.2 ± 10.3* | 129.6 ± 9.2* | 90.5 ± 13.3 |
| Tightrope | Suspension time (s) | 44.2 ± 3.4 | 56.2 ± 1.8* | 55.1 ± 1.9* | 53.4 ± 2.3* |
| Tightrope score | 53.9 ± 3.5 | 86.3 ± 4.2* | 77.6 ± 5.7* | 68.4 ± 7.0 | |
| Open field | Latency (s) | 6.36 ± 0.7 | 11.7 ± 1.7* | 10.8 ± 1.3* | 8.5 ± 1.0 |
| Number of squares crossed | 123.6 ± 6.5 | 159.3 ± 9.7* | 121.4 ± 6.0 | 106.6 ± 7.0 | |
| Peripheral time (s) | 230.9 ± 10.2 | 261.0 ± 7.6* | 237.3 ± 12.0 | 228.9 ± 10.9 |
The results were expressed as mean ± SEM
*P < 0.05 denotes significant difference compared to the old controls