Table 2.
Performances of the SAMP8 mice in the memory tasks
| Tasks | Phases | Parameters | Old control | Young control | HD-DNJ group | LD-DNJ group |
|---|---|---|---|---|---|---|
| Novel object recognition | 10-min phase | Tt (s) | 7.7 ± 0.6 | 13.0 ± 1.4* | 6.7 ± 0.3 | 7.6 ± 0.6 |
| PI (%) | 49.2 ± 2.6 | 62.6 ± 1.1* | 65.8 ± 3.0* | 63.2 ± 3.4* | ||
| 24-h phase | Tt (s) | 6.4 ± 0.3 | 12.2 ± 1.0* | 7.2 ± 0.4 | 7.2 ± 0.3 | |
| PI (%) | 48.5 ± 3.1 | 47.4 ± 1.7 | 52.7 ± 3.2 | 51.6 ± 3.1 | ||
| Novel location recognition | 10-min phase | Tt (s) | 5.7 ± 0.5 | 8.3 ± 0.6* | 5.9 ± 1.3 | 5.6 ± 0.8 |
| PI (%) | 51.0 ± 3.7 | 63.9 ± 2.8* | 63.7 ± 3.4* | 61.1 ± 5.1* | ||
| 24-h phase | Tt (s) | 5.2 ± 0.6 | 6.7 ± 0.5 | 5.1 ± 0.5 | 4.5 ± 0.4 | |
| PI (%) | 51.6 ± 4.2 | 57.5 ± 3.1 | 54.7 ± 4.7 | 51.1 ± 4.3 | ||
| Episodic-like memory | Tt (s) | 23.1 ± 0.6 | 38.3 ± 0.7* | 30.0 ± 1.0* | 36.2 ± 1.6* | |
| PIo (%) | 50.4 ± 0.8 | 59.6 ± 0.7* | 55.5 ± 0.8* | 56.4 ± 1.0* | ||
| PIod (%) | 49.6 ± 2.8 | 57.8 ± 0.8* | 55.9 ± 0.8* | 54.8 ± 0.4* | ||
Data are expressed as mean ± SEM
PI preference index for novel object in the NOR or for novel location in the NLR, PIo preference index for old objects, PIod preference index for displaced old object, Tt total exploring time
*P < 0.05 denotes significant difference compared to the old controls