Table 6.
Correlations between InsR in each hippocampal layer and memory ability
| Groups | Layers in subregions | Morris water maze | Novel object recognition | Novel location recognition | Episodic-like memory | ||
|---|---|---|---|---|---|---|---|
| Swimming distance | %of distance in the target quadrant | PI | PI | PIo | PIod | ||
| r (P) | r (P) | r (P) | r (P) | r (P) | r (P) | ||
| All mice | DG-HL | −0.427** (0.002) | 0.469** (0.001) | 0.243 (0.085) | 0.150 (0.293) | 0.252 (0.074) | 0.089 (0.534) |
| DG-GL | −0.373** (0.007) | 0.423** (0.002) | 0.357* (0.010) | 0.376** (0.007) | 0.432** (0.002) | 0.346* (0.013) | |
| DG-ML | −0.480** (0.000) | 0.478** (0.000) | 0.251 (0.076) | 0.336* (0.016) | 0.371** (0.007) | 0.167 (0.242) | |
| CA1-ML | −0.627** (0.000) | 0.360** (0.009) | 0.463** (0.001) | 0.227 (0.110) | 0.358* (0.010) | 0.050 (0.727) | |
| CA1-RL | −0.563** (0.000) | 0.364** (0.009) | 0.409** (0.003) | 0.188 (0.186) | 0.268 (0.058) | 0.013 (0.929) | |
| CA1-PL | −0.375** (0.007) | 0.264 (0.061) | 0.477** (0.000) | 0.313* (0.026) | 0.311* (0.026) | 0.215 (0.129) | |
| CA1-OL | −0.596** (0.000) | 0.281* (0.046) | 0.526** (0.000) | 0.256 (0.070) | 0.380** (0.006) | 0.426** (0.002) | |
| CA3-ML | −0.521** (0.000) | 0.146 (0.306) | 0.388** (0.005) | 0.214 (0.131) | 0.417** (0.002) | 0.169 (0.236) | |
| CA3-SL | −0.193 (0.175) | −0.012 (0.932) | 0.289* (0.040) | 0.460** (0.001) | 0.124 (0.386) | 0.468** (0.001) | |
| CA3-PL | −0.082 (0.572) | 0.025 (0.859) | 0.113 (0.428) | 0.188 (0.187) | 0.448** (0.001) | 0.139 (0.329) | |
| CA3-OL | −0.395** (0.005) | 0.076 (0.602) | 0.307* (0.032) | 0.142 (0.329) | 0.185 (0.204) | 0.107 (0.462) | |
| O-con | DG-HL | −0.277 (0.442) | 0.992** (0.000) | −0.453 (0.210) | −0.391 (0.308) | −0.585 (0.078) | −0.084 (0.743) |
| DG-ML | −0.195 (0.589) | 0.860** (0.003) | −0.207 (0.410) | 0.070 (0.848) | −0.358 (0.344) | −0.006 (0.849) | |
| CA1-ML | −0.725* (0.015) | 0.187 (0.558) | 0.394 (0.284) | −0.183 (0.594) | −0.142 (0.667) | 0.142 (0.676) | |
| Y-con | CA1-PL | 0.189 (0.626) | 0.704* (0.011) | 0.281 (0.401) | −0.450 (0.142) | 0.019 (0.958) | 0.223 (0.501) |
| CA1-OL | −0.643* (0.024) | 0.158 (0.624) | 0.179 (0.579) | 0.173 (0.592) | 0.528 (0.078) | 0.414 (0.181) | |
| HD-DNJ | DG-GL | 0.219 (0.458) | −0.034 (0.907) | 0.803** (0.001) | 0.229 (0.431) | −0.068 (0.817) | 0.123 (0.676) |
| CA1-RL | −0.361 (0.205) | −0.067 (0.820) | 0.679** (0.008) | 0.036 (0.902) | −0.072 (0.806) | 0.744** (0.002) | |
| CA1-OL | −0.629* (0.016) | 0.151 (0.605) | 0.576 (0.031) | −0.119 (0.685) | −0.325 (0.257) | 0.788** (0.001) | |
| LD-DNJ | DG-ML | 0.016 (0.961) | −0.360 (0.250) | 0.755** (0.005) | 0.150 (0.641) | 0.442 (0.151) | 0.444 (0.149) |
| CA1-PL | −0.373 (0.232) | 0.526 (0.079) | 0.807** (0.002) | −0.353 (0.261) | −0.199 (0.536) | −0.160 (0.620) | |
PI preference index for novel object in the NOR or for novel location in the NLR, PIo preference index for old objects, PIod preference index for displaced old object
*P < 0.05, ** P < 0.01 denote significant correlation coefficients