Table 2.
SIRT1 SNP main effects on change in lung function stratified by overweight status
| Outcome | SNP | Eff. all. | Freq | Normal weight (n = 858) | Overweight (n = 274) | All (n = 1132) | |||
|---|---|---|---|---|---|---|---|---|---|
| β-coeff. (95 % CI) | p | β-coeff. (95 % CI) | p | β-coeff. (95 % CI) | p | ||||
| Change in FEV1 (in mL) | rs730821 a | C | 0.3 | 3 (−27 to 34) | 0.83 | -11 (−75 to 53) | 0.74 | 0 (−28 to 27) | 0.98 |
| rs10997868 | C | 0.68 | -11 (−35 to 14) | 0.41 | -21 (−77 to 35) | 0.46 | -12 (−35 to 11) | 0.30 | |
| rs10823116 | G | 0.13 | -20 (−73 to 33) | 0.46 | -117 (−242 to 9) | 0.068 | -38 (−88 to 12) | 0.13 | |
| Change in FVC (in mL) | rs730821 a | C | 0.38 | 0 (−43 to 44) | 0.99 | -4 (−85 to 78) | 0.93 | 1 (−38 to 39) | 0.97 |
| rs10997868 | C | 0.68 | -13 (−49 to 23) | 0.48 | -33 (−106 to 41) | 0.38 | -14 (−46 to 19) | 0.41 | |
| rs10823116 | G | 0.13 | -39.2 (−106 to 28) | 0.25 | -84 (−248 to 80) | 0.32 | -42 (−105 to 22) | 0.20 | |
| Change in FEV1/FVC (in percent) | rs730821 a | C | 0.38 | 0.1 (−0.5 to 0.6) | 0.80 | -0.2 (−1.2 to 0.9) | 0.75 | 0.0 (−0.5 to 0.4) | 0.85 |
| rs10997868 | C | 0.68 | 0.0 (−0.4 to 0.4) | 0.93 | 0.1 (−0.8 to 1.0) | 0.84 | 0.0 (−0.4 to 0.3) | 0.85 | |
| rs10823116 | G | 0.13 | 0.2 (−0.6 to 1.1)* | 0.64 | -1.8 (−3.9 to 0.3)* | 0.099 | -0.3 (−1.1 to 0.5) | 0.48 | |
| Change in FEF25–75 (in mL/s) | rs730821 a | C | 0.38 | 9 (−52 to 71) | 0.77 | -19 (−156 to 118) | 0.79 | -4 (−61 to 52) | 0.88 |
| rs10997868 | C | 0.68 | -13 (−62 to 37) | 0.62 | -10 (−128 to 108) | 0.87 | -18 (−65 to 28) | 0.45 | |
| rs10823116 | G | 0.13 | 47 (−57 to 150)* | 0.37 | -244 (−495 to 6)* | 0.056 | -20 (−117 to 78 | 0.69 | |
Estimates are given per effect allele. Negative values mean an acceleration and positive an attenuation of lung function decline. All models were adjusted for percent predicted baseline value of lung function, sex, age (centered to median), height (centered to median), educational level, and study area
FEV1 forced expiratory volume in 1 s of expiration, FVC forced vital capacity, FEF 25–75 forced expiratory flow between 25th and 75th percentile of FVC, overweight BMI ≥ 75th percentile of the observed distribution, Eff. all. effect allele, Freq effect allele frequency, β-coeff beta-coefficient, 95 % CI 95 % confidence interval, p p value
*Statistically significant interaction (p < 0.05)
a n = 1130 in whole study sample and n = 856 in normal weight due to missing genotype data