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. 2016 Aug 31;6:188. doi: 10.3389/fonc.2016.00188

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Copyright © 2016 Azad, Rajwa and Pothen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The template tree created by HM&M algorithm from all samples of the HD dataset. Leaves of the dendrogram denote samples from five healthy individuals. An internal node represents a template, and the height of an internal node measures the dissimilarity between its left and right children. The sample-specific subtrees are drawn in different colors. (B) Bivariate projections of the combined template [the root of the tree in (A)] are drawn in terms of its meta-clusters. Here, each meta-cluster is represented by a homogeneous collection of cell clusters that are drawn with the 95th quantile contour lines. Clusters participating in a meta-cluster are drawn in same color.