Table 4.
Associations of family history measures as predictors of age-adjusted breast cancer incidence for the sub-cohort of 17 403 women in ProF-SC who were unaffected at baseline
| Family history measure | Number of events | Person-time (yrs) | Hazard ratio estimate a | 95% confidence interval | χ 12 |
|---|---|---|---|---|---|
| Breast cancer in 1st-degree relative(s) (yes/no, binary categorical) | 1070 | 175186 | 1.45 | (1.22, 1.73) | 18 |
| Number of 1st-degree relatives with breast cancer (ordered categorical) | 1070 | 175186 | 1.39 | (1.29, 1.49) | 81 |
| BOADICEA 10-year risk (per 1% change, continuous) | 947 | 154885 | 1.12 | (1.11, 1.14) | 523 |
| Breast cancer in 1st-degree relative(s) (yes/no, binary categorical) | 947 | 154885 | 1.22 | (1.01, 1.47) | 4 |
| BOADICEA 10-year risk (per 1% change, continuous) | 1.12 | (1.11, 1.13) | 503 | ||
| Number of 1st-degree relatives with breast cancer (ordered categorical) | 947 | 154885 | 1.17 | (1.08, 1.27) | 14 |
| BOADICEA 10-year risk | 1.12 | (1.11, 1.13) | 428 | ||
| (per 1% change, continuous) | |||||
a Each row represents a separate age-adjusted model; rows 4 and 5 report models in which two constructs of family history are simultaneously fitted.