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. 2016 Mar 12;45(3):728–740. doi: 10.1093/ije/dyv364

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© The Author 2016. Published by Oxford University Press on behalf of the International Epidemiological Association.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0/ ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Polygenic risk scores demonstrate overlap between diseases. Hodgkin lymphoma (HL) and multiple sclerosis (MS) polygenic risk scores in HL cases, MS cases and healthy controls. A. MS genetic burden (MSGB) on y-axis, an aggregate measure of MS genetic risk across the genome of a given individual (includes human leukocyte antigen region of chromosome 6). MSGB is higher in HL cases than controls, indicating genetic overlap between HL and MS. B. HL genetic burden (HLGB) on y-axis, an aggregate measure of HL genetic risk across the genome of a given individual (includes human leukocyte antigen region of chromosome 6). HLGB is higher in MS cases than controls, indicating genetic overlap between HL and MS.