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. 2016 May 24;45(3):806–815. doi: 10.1093/ije/dyw052

Table 2.

Associations between hydrogen sulphide (H 2 S  in quartiles and continuous) and cause specific mortality: number of deaths (No.)   hazard ratios (HR) and 95% confidence intervals (95% CI)

Cause of death (ICD-9-CM) H 2 S concentrations
<25° percentile a 25°–50° percentile
50°–75° percentile
>75° percentile
Linear trend
No. No. Crude HR HR 95% CI No. Crude HR HR 95% CI No. Crude HR HR 95% CI HR 95% CI
Natural causes (001–799) 3 701 3 946 0.98 1.01 (0.96–1.06) 4 254 1.00 1.02 (0.97–1.08) 4 104 0.96 0.98 (0.91–1.05) 1.00 (0.98–1.02)
All cancers (140–239) 1 282 1 307 0.97 0.99 (0.91–1.08) 1 493 1.03 1.05 (0.95–1.16) 1 452 1.00 1.03 (0.91–1.16) 1.01 (0.98–1.05)
 Stomach (151) 75 88 1.03 0.98 (0.70–1.37) 108 1.27 1.23 (0.84–1.79) 105 1.00 0.88 (0.54–1.42) 1.00 (0.87–1.16)
 Colorectal (153–154,159) 154 170 0.99 1.00 (0.79–1.27) 176 0.96 0.97 (0.74–1.28) 159 0.93 0.91 (0.64–1.28) 0.97 (0.87–1.08)
 Liver (155–156) 102 89 0.86 0.83 (0.61–1.13) 106 0.89 0.77 (0.53–1.11) 89 0.74 0.76 (0.48–1.2) 0.90 (0.78–1.05)
 Pancreas (157) 68 64 0.92 0.93 (0.64–1.35) 69 0.92 0.95 (0.61–1.49) 72 0.69 0.73 (0.41–1.32) 0.93 (0.77–1.11)
 Larynx (161) 17 15 0.81 0.72 (0.33–1.56) 11 0.38 0.40 (0.14–1.14) 23 0.43 0.26 (0.07–0.95) 0.64 (0.43–0.97)
 Lung (162) 276 281 0.98 1.06 (0.89–1.27) 360 1.09 1.18 (0.97–1.45) 361 1.19 1.34 (1.06–1.71) 1.10 (1.02–1.19)
 Bladder (188) 54 48 0.88 0.89 (0.59–1.36) 56 1.22 1.33 (0.81–2.16) 50 1.01 0.94 (0.5–1.80) 1.03 (0.85–1.26)
 Kidney (189) 36 30 0.76 0.85 (0.51–1.43) 36 0.87 0.94 (0.52–1.70) 31 0.70 0.86 (0.41–1.83) 0.96 (0.75–1.22)
 Brain (191) 23 29 1.26 1.25 (0.70–2.26) 38 1.63 1.63 (0.84–3.17) 41 1.70 1.76 (0.81–3.81) 1.22 (0.95–1.56)
 Lymphatic and haematopoietic tissue (200–208) 108 115 1.03 1.16 (0.87–1.54) 106 0.94 0.96 (0.68–1.35) 102 1.06 1.12 (0.74–1.17) 1.02 (0.89–1.16)
Cardiovascular diseases (390–459) 1 457 1 681 1.02 1.05 (0.97–1.13) 1 676 0.96 1.00 (0.91–1.09) 1 641 0.90 0.91 (0.81–1.02) 0.98 (0.94–1.01)
 Ischaemic heart diseases (410–414) 512 570 0.99 1.00 (0.88–1.14) 574 0.86 0.91 (0.78–1.06) 530 0.77 0.78 (0.64–0.95) 0.93 (0.87–0.99)
Respiratory diseases (460–519) 256 244 0.88 0.92 (0.76–1.11) 279 1.15 1.13 (0.90–1.40) 264 1.30 1.30 (0.99–1.70) 1.09 (1.00–1.19)
Digestive diseases (520–579) 158 163 0.93 0.97 (0.77–1.24) 218 1.06 1.09 (0.83–1.41) 186 0.94 0.97 (0.69–1.35) 1.01 (0.91–1.12)
Urinary system diseases (580–599) 58 92 1.49 1.54 (1.08–2.21) 74 1.25 1.28 (0.83–1.97) 67 1.26 1.42 (0.84–2.40) 1.11 (0.94–1.30)

a Reference category