Figure 3. Lower body weight, reduced fat mass, decreased blood glucose, higher plasma lactate, and reduced insulin in Ip6k3^−/− mice.

Body weight (a), lean mass (b), fat mass (c), blood glucose (d), plasma lactate (e), and plasma insulin (f) of Ip6k3^−/− mice and their wild-type littermates at the indicated ages. The observations became evident with ageing. B6.Cg-Ip6k3^−/− and wild-type littermates were used for the analysis. The mean values and individual values are shown. *P < 0.05 and **P < 0.01 by the Student’s t-test, and ^†P < 0.05 and ^††P < 0.01 by the Aspin-Welch test. n = 30 for 8 and 12 weeks old wild-type and Ip6k3^−/− mice, n = 24 for 24 weeks old wild-type and Ip6k3^−/− mice, n = 27 and 28 for 51 weeks old wild-type and Ip6k3^−/− mice, n = 28 and 29 for 1.5 years old wild-type and Ip6k3^−/− mice.