Table 1. Maternal and embryo physiological conditions changed in response to LPS plus or minus NAC exposure on GD 18.
| Parameters | Vehicle | LPS (0.25 μg/kg) | LPS (2.5 μg/kg) | LPS (12.5 μg/kg) | LPS (25 μg/kg) | LPS (2.5 μg/kg) + NAC | LPS (25 μg/kg) + NAC | LPS (25 μg/kg) + Asc |
|---|---|---|---|---|---|---|---|---|
| Spleen Weight (%) | 100 ± 14.8 | 82 ± 0.1 | 106 ± 12.6 | 107 ± 2.5 | 202 ± 21.7*** | 108 ± 1.9 | 112 ± 9.8# | 154 ± 29.1*** |
| Placenta Weight (g) | 0.35 ± 0.06 | 0.31 ± 0.04 | 0.36 ± 0.05 | 0.32 ± 0.05 | 0.42 ± 0.09* | 0.38 ± 0.05 | 0.32 ± 0.06### | 0.41 ± 0.10### |
| Placenta Area (cm2) | 1.36 ± 0.10 | 1.31 ± 0.11 | 1.34 ± 0.11 | 1.29 ± 0.13 | 1.31 ± 0.11** | 1.30 ± 0.07 | 1.31 ± 0.16 | 1.34 ± 0.20 |
| Embryo Weight (g) | 0.94 ± 0.13 | 0.95 ± 0.13 | 0.95 ± 0.16 | 0.91 ± 0.09 | 1.09 ± 0.22** | 0.99 ± 0.13 | 0.94 ± 0.13 | 0.90 ± 0.08***,# |
| Hemoglobin (g/dL) | 16.4 ± 2.68 | 15.3 ± 0.52 | 14.0 ± 0.93 | 12.5 ± 5.67 | 13.5 ± 2.96*** | 14.5 ± 0.84 | 15.1 ± 1.05## | 11.8 ± 1.60 |
| RBC (109/mL) | 6.48 ± 2.27 | 6.59 ± 0.57 | 4.78 ± 1.26 | 4.66 ± 0.60 | 3.62 ± 1.31*** | 6.91 ± 2.08 | 5.81 ± 0.37# | 5.23 ± 2.21* |
| WBC (106/mL) | 8.94 ± 2.22 | 8.90 ± 1.03 | 8.62 ± 4.95 | 9.86 ± 3.11 | 14.4 ± 3.98 | 10.8 ± 4.22 | 8.53 ± 2.98 | 12.3 ± 1.55 |
The results are presented as means ± SD of three independent experiments and duplicate measurements.
*p < 0.05, indicates that the mean is significantly different from the control by ANOVA with Kruskal–Wallis test followed by Dunn’s multiple comparisons test.
#p < 0.05, indicates that the mean is significantly different from the LPS (25 μg/kg) group by ANOVA with Kruskal–Wallis test followed by Dunn’s multiple comparisons test.