Table 3.
Primary and secondary outcomes and mean event free times up to 180 days
| Incomplete B-line data (n = 10) | 0 B-lines (n = 72) | 1–2 B-lines (n = 54) | ≥3 B-lines (n = 59) | |
|---|---|---|---|---|
| Primary outcome | ||||
| 6-month HF hospitalization | 4 (40) | 10 (14) | 10 (19) | 24 (41) |
| Death | 2 (20) | 1 (1) | 5 (9) | 7 (12) |
| Primary composite outcome (first event) | 4 (40) | 11 (15) | 12 (22) | 27 (46) |
| Unadjusted HR (95% CI) | – | 1 | 1.50 (0.66, 3.41) P = 0.328 | 3.78 (1.88, 7.63) P<0.001 |
| Adjusted HR* (95% CI) | – | 1 | 1.58 (0.70, 3.59) P = 0.275 | 4.08 (1.95, 8.54) P < 0.001 |
| RMST* (95% CI) | – | 165 days (155, 175) | 156 days (143, 169) P = 0.285 (adj. P = 0.173) | 125 days (107, 144) P < 0.001 (adj. P < 0.001) |
| Secondary outcome | ||||
| 6-month urgent HF visits | 1 (25) | 2 (5) | 3 (7) | 3 (9) |
| Secondary composite outcome (first event) | 4 (40) | 13 (18) | 15 (28) | 29 (49) |
| Unadjusted HR (95% CI) | – | 1 | 1.56 (0.74, 3.31) P = 0.242 | 3.44 (1.79, 6.64) P < 0.001 |
| Adjusted HR* (95% CI) | – | 1 | 1.61 (0.75, 3.42) P = 0.219 | 3.45 (1.72, 6.93) P < 0.001 |
| RMST* (95% CI) | – | 161 days (149, 172) | 152 days (139, 166) P = 0.346 (adj. P = 0.287) | 121 days (102, 139) P < 0.001 (adj. P < 0.001) |
| Censored events | ||||
| VAD placement | 0 | 2 (3) | 0 | 0 |
| Loss to follow-up (for HF hospitalization) | 0 | 3 (4) | 0 | 1 (2) |
VAD, ventricular assist device.
Primary outcome: *Unadjusted model: c-statistic 0.655. Adjusted model: covariates: age, gender, NYHA class III or IV, and congestion score (c-statistic: 0.723).
Secondary outcome: All analyses were adjusted for availability of ambulatory unit for urgent HF visits. *Unadjusted model: c-statistic 0.643. Adjusted model: covariates: age, gender, NYHA class III or IV, and congestion score (c-statistic: 0.700).