Table 3.
Association between genotypes and alleles of adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) gene variants and risk of colorectal cancera.
| Gene (variant) | Controls (n = 339) | Cases (n = 261) | OR (95%CI) P-valueb |
|---|---|---|---|
| ADIPOQ (rs2241766) | |||
| Genotype-wise comparison | |||
| TT | 240(70.8) | 199(76.2) | 1.0(reference) |
| TG | 82(24.2) | 55(21.1) | 0.87(0.57–1.33)0.520 |
| GG | 17(5.0) | 7(2.7) | 0.44(0.17–1.14)0.092 |
| TG and GG | 99(29.2) | 62(23.8) | 0.79(0.53–1.17)0.241 |
| GG versus others | 17(5.0) | 7(2.7) | 0.45(0.18–1.17)0.103 |
| Allele-wise comparison | |||
| T | 562(82.9) | 453(86.8) | 1.0(reference) |
| G | 116(17.1) | 69(13.2) | 1.36(0.98–1.87)0.064 |
| ADIPOR1 (rs2275738) | |||
| Genotype-wise comparison | |||
| TT | 109(32.2) | 63(24.1) | 1.0(reference) |
| TC | 154(45.4) | 134(51.4) | 1.50(0.99–2.29)0.056 |
| CC | 76(22.4) | 64(24.5) | 1.45(0.89–2.37)0.139 |
| TC and CC | 230(67.8) | 198(75.9) | 1.49(1.00–2.20)0.048 |
| CC versus others | 76(22.4) | 64(24.5) | 1.12(0.74–1.70)0.579 |
| Allele-wise comparison | |||
| T | 372(54.9) | 260(49.8) | 1.0(reference) |
| C | 306(45.1) | 262(50.2) | 0.82(0.65–1.03)0.082 |
Boldface data indicates significance at P-value < 0.05.
a
Variables presented as number (%).
b
Adjusted for age, BMI, sex, smoking status, NSAID use, and family history in genotype-wise comparisons.