Table 1.
Characteristics of included studies.
| Studies | Study location | Indication of warfarin | Number of sample(ALL/M) | Age | INR target range | Genotype frequencies |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CYP2C9 |
CYP4F2 |
VKORC1 1173 |
VKORC1-1639 |
|||||||||||||||
| *1/*1 | *1/*3 | *3/*3 | CC | CT | TT | TT | TC | CC | AA | GA | GG | |||||||
| 1 | Cen et al. (2010) | Guangdong | MHVR | 222/104 | 45 ± 12 | 1.8–2.4 | 91.0 | 8.0 | 1.0 | 52.0 | 41.0 | 7.0 | – | – | – | – | – | – |
| 2 | Chen et al. (2014) | Beijing | HVR,AF | 551/308 | 51 (43–60) | 1.6–2.5 | 91.2 | 8 | 0.2 | 52.3 | 38.8 | 8.9 | – | – | – | – | – | – |
| 3 | Cheng et al. (2009) | Fujian | AF, HVR | 248/132 | 68.86 ± 6.09 | 1.5–3.0 | 86.7 | 12.1 | 1.2 | – | – | – | – | – | – | 65.3 | 26.6 | 8.1 |
| 4 | Du et al. (2010) | Beijing | AF,DVT,HVR,PE | 190/109 | 60 (18–89) | 1.5–3.0 | 91.58 | 8.42 | 0 | – | – | – | – | – | – | 85.79 | 13.16 | 1.05 |
| 5 | Gao et al. (2010) | Fujian | MHVR | 119/50 | 44.58 | 1.5–2.5 | 92.44 | 7.56 | 0 | – | – | – | – | – | – | 84.03 | 15.97 | 0 |
| 6 | Gu et al. (2010) | Chongqing | MHVR | 127/59 | 44.3 ± 17.6 | 1.5–2.0 | 85 | 12.6 | 2.4 | – | – | – | – | – | – | – | – | – |
| 7 | Huang et al. (2009a) | Guangdong | HVR,AF,DVT | 266/123 | 51.5 ± 15.0 | 1.8–3.0 | 90.2 | 9.4 | 0.4 | – | – | – | 77.4 | 21.1 | 1.5 | – | – | – |
| 8 | Huo et al. (2008) | Guangdong | HVR | 93/45 | 21–62 | 1.5–2.0 | 84.95 | 15.05 | 0 | – | – | – | – | – | – | – | – | – |
| 9 | Jiang et al. (2007) | Jiangsu | / | 102/51 | 53.6 ± 16 | 1.5–2.5 | – | – | – | – | – | – | 81.4 | 15.7 | 2.9 | – | – | – |
| 10 | Li et al. (2012) | Jiangxi | MVR,AVR,DVR | 352/123 | 61.8 ± 6.6 | 1.8–2.5 | – | – | – | 58 | 34.9 | 7.1 | – | – | – | – | – | – |
| 11 | Li and Sheng (2010) | Jiangsu | HVR,AF | 73/41 | 54.98 ± 14.10 | 1.5–3.0 | 80.82 | 16.44 | 2.74 | – | – | – | – | – | – | 76.71 | 19.18 | 4.11 |
| 12 | Liang et al. (2012b) | Beijing | AF,DVT,PE,HVR | 115/71 | 64.9 ± 13.0 | 2.0–3.0 | 92.2 | 7.8 | 0 | 41.7 | 47.8 | 10.4 | – | – | – | 85.2 | 14.8 | 0 |
| 13 | Liang et al. (2013) | Yunnan | – | 300/138 | 47.9 ± 12.5 | 1.5–3.0 | 92 | 7.3 | 0.7 | 57.3 | 40 | 2.7 | – | – | – | – | – | – |
| 14 | Liu and Zhang (2010) | Beijing | PE | 108/46 | 59.02 | 2.0–3.0 | – | – | – | – | – | – | – | – | – | 77.78 | 21.3 | 0.92 |
| 15 | Lou et al. (2012) | Beijing | HVR,AF | 161/89 | 64.53 | 1.5–3.0 | 87.58 | 12.42 | 0 | – | – | – | – | – | – | – | – | – |
| 16 | Lu et al. (2013) | Jiangsu | MHVR | 197/82 | 47.0 (18–76) | 1.5–2.8 | 94.4 | 5.6 | 0 | – | – | – | – | – | – | 80.7 | 18.8 | 0.5 |
| 17 | Ma et al. (2012) | Beijing | AF,DVT,PE,HVR | 312/119 | 56.6 ± 16.0 | 1.6–3.0 | 87.8 | 12.2 | 56.1 | 43.9 | – | – | – | 84.9 | 15.1 | |||
| 18 | Meng et al. (2011) | Jiangsu | RHD, AF, DVT | 125/48 | 51.16 | 1.8–3.0 | – | – | – | – | – | – | 87.2 | 12 | 0.8 | 87.2 | 12 | 0.8 |
| 19 | Miao et al. (2007) | Jiangsu | AF,DVT,PE,HVR | 178/74 | 54.7 | 1.5–3.0 | 91 | 9 | 0 | – | – | – | – | – | – | 83.7 | 15.7 | 0.6 |
| 20 | Tan et al. (2013) | Hunan | MHVR. | 317/95 | 45.2 ± 10.5 | 2.1–2.8 | 91.5 | 7.9 | 0.6 | 63.4 | 33.75 | 2.84 | – | – | – | 80.7 | 18 | 1.3 |
| 21 | Tang et al. (2009) | Beijing | VTE | 205/108 | 60.1 ± 13.8 | 2.0–3.0 | – | – | – | – | – | – | 86.8 | 12.2 | 1 | – | – | – |
| 22 | Veenstra et al. (2005) | Hongkong | AF, DVT, RHD | 69/32 | 58.0 ± 10.0 | 1.8–3.2 | 94.2 | 5.8 | 0 | – | – | – | – | – | – | 76.8 | 20.3 | 2.9 |
| 23 | Wang and Zhong (2013) | Sichuan | Orthopedic Surgery | 214/114 | 51.6 ± 7.5 | 2.0–3.0 | 90.7 | 8.4 | 0.9 | – | – | – | – | – | – | 79.9 | 19.2 | 0.9 |
| 24 | Wang et al. (2011) | Liaoning | / | 196/80 | 61.89 | 1.8–3.0 | – | – | – | 50.51 | 42.86 | 6.63 | – | – | – | – | – | – |
| 25 | Wei et al. (2012) | Jiangsu | NVAF,DVT,MHVR | 325/153 | 66.5 ± 12.9 | 1.5–3.0 | 90.8 | 9.2 | 0 | 56 | 33.3 | 10.8 | 86.8 | 12.9 | 0.3 | |||
| 26 | Yang et al. (2011) | Jiangsu | / | 178/74 | 55.3 | 1.5–3.0 | – | – | – | – | – | – | 86.5 | 12.9 | 0.56 | – | – | – |
| 27 | Yuan et al. (2005) | Taiwan | / | 104/56 | 58.6 ± 14.4 | 1.58–2.55 | – | – | – | – | – | – | – | – | – | 79.8 | 18.3 | 1.9 |
| 28 | Zhang et al. (2012b) | Jiangsu | MHVR | 197/82 | 52.92 ± 11.76 | 1.5–2.8 | – | – | – | 58.38 | 37.06 | 4.57 | – | – | – | – | – | – |
| 29 | Zhang et al. (2007a) | Xinjiang | HVR | 88/41 | 45.1 | 1.5–2.0 | 77.27 | 14.77 | 0 | – | – | – | – | – | – | – | – | – |
| 30 | Zhang et al. (2012a) | Beijing | VTE,PE | 297/148 | 64 | 2.0–3.0 | 91.2 | 8.8 | 0 | – | – | – | 85.5 | 13.8 | 0.7 | – | – | – |
| 31 | Zhang et al. (2007b) | Fujian | RHD,AF | 129/52 | 45.79 ± 12.06 | 1.5–3.0 | 90.7 | 8.15 | 0.8 | – | – | – | – | – | – | 74.42 | 23.26 | 2.3 |
| 32 | Zheng et al. (2008) | Beijing | / | 123 | / | / | 92.68 | 6.5 | 0 | – | – | – | – | – | – | – | – | – |
| 33 | Zhuang et al. (2014) | Shanghai | AF,DVT,HVR | 214/110 | 65.72 ± 10.59 | 1.5–3.0 | 92.52 | 7.48 | 0 | 57.94 | 42.06 | 82.71 | 17.29 | 0 | – | – | – | |