Table 1.
Characteristic | Classification | ≥ Second-Line Patients (N = 78) |
---|---|---|
Age, years | Median (range) | 66 (28–85) |
Sex, n (%) | Female/male | 39 (50)/39 (50) |
Race, n (%) | White | 59 (76) |
Asian | 17 (22) | |
African American | 2 (3) | |
ECOG PS at baseline, n (%) | 0 | 16 (21) |
1 | 50 (64) | |
2 | 12 (15) | |
Smoking history, n (%) | Never smokera | 29 (37) |
Smoker ≤ 30 pack-yearsb | 25 (32) | |
Smoker > 30 pack-yearsb | 24 (31) | |
Histology at initial diagnosis, n (%) | Adenocarcinoma | 75 (96) |
Otherc | 3 (4) | |
Number of prior systemic regimens for metastatic disease, n (%) | 1 | 40 (51) |
2 | 14 (18) | |
3 | 24 (31) | |
Time since last progression, months (n = 71) | Median (IQR) | 1·1 (0·7–2·1) |
ECOG denotes Eastern Cooperative Oncology Group, PS performance status.
The definition of never-smokers was at the discretion of the local sites.
Among 49 smokers, 3 current smokers, and 46 former smokers.
“Other” includes 1 patient with adenosquamous carcinoma, predominately squamous cell carcinoma; 1 patient with bronchioalveolar carcinoma, mucinous type; and 1 patient with large cell carcinoma, adenocarcinoma.