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. 2015 Nov 5;61(Suppl 6):S652–S661. doi: 10.1093/cid/civ818

Figure 3.

Figure 3.

Trends in aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP), from baseline to end of treatment (EOT) of intermittent administration of high-dose micafungin for patients with normal liver function at baseline. Normal liver function was defined as AST or ALT <3 times the upper limit of normal (ULN) and/or ALP <2 times the ULN. Shaded regions represent the interquartile range. Capped whiskers represent the 10th and 90th percentiles. Values of ALT were compared between baseline (week [W] 0) and W1, W2, W4, W6, W8, and EOT. The Wilcoxon signed-rank test was used to assess the difference between the paired samples. P values between W0 and W1, W2, W4, W6, and W8 were .04, .12, .29, .03, and .02, respectively, for AST; .52, .86, .14, .43, and .09, respectively, for ALT; and .006, .03, .01, .005, and .002, respectively, for ALP.