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. 2016 Mar 3;19(8):pyw021. doi: 10.1093/ijnp/pyw021

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© The Author 2016. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) attenuated methamphetamine (METH)-induced decreases in tyrosine hydroxylase (TH) and dopamine transporter (DAT) expression in the striatum. Hc-TeTx (Hc) prevents the striatal TH and DAT decrease induced by METH. Photomicrographs of striatal sections stained for TH (A) and DAT (B) from mice at 1, 3, and 7 days after METH with and without Hc-TeTx treatment. Histograms show the percentage of striatal stained area of TH-immunoractive (TH-ir) (C) and DAT-ir (D) in the striatum. (E) METH (4mg/kg, 3 consecutive administrations each 3 hours apart) produced hyperthermia in mice after the injections Arrows indicate drug injections. Data represent mean±SEM, n=6–8/group, using 4–5 sections/animal. *P<.05, ***P<.001 vs saline group, #P<.05, ###P<.001 vs METH only. Bar indicates 500 µm.