Figure 2.

C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) attenuated methamphetamine (METH)-induced increases in amino-cupric-silver technique (A–Cu–Ag) staining in the striatum. METH induced an increase in A–Cu–Ag staining indicative of cell damage that was mitigated by treatment with Hc-TeTx (Hc). Photomicrographs of A–Cu–Ag-stained sections of the striatum of mice at 3 and 7 days after METH with and without Hc treatment. Histograms show the proportional stained area in the striatum. Data represent mean±SEM, n=6–8/group. *P<.05, **P<.01, ***P<.001 vs saline group; #P<.05, ###P<.001 vs METH group. Bar indicates 500 μm.