Table 1.
Description of exome sequencing validation sample
| Variable | Lung cancer cases with emphysema (n = 267) | Lung cancer cases without emphysema (n = 345) | P homogeneity |
|---|---|---|---|
| Sex (n, %) | |||
| Male | 78 (29.2) | 111 (32.2) | 0.432 |
| Female | 189 (70.8) | 234 (67.8) | |
| Race (n, %) | |||
| White | 127 (47.6) | 133 (38.6) | 0.025 |
| Black | 140 (52.4) | 212 (61.4) | |
| Age (mean, SD) | 61.8 (9.7) | 58.7 (11.1) | <0.001 |
| Emphysema (n, %) | |||
| No | 0 | 345 (100.0) | — |
| Yes | 267 (100.0) | 0 | |
| Education years (mean, SD) | 12.0 (2.3) | 12.7 (2.6) | <0.001 |
| Family history of lung cancer (n, %) | |||
| No | 219 (82.0) | 275 (79.7) | 0.472 |
| Yes | 48 (18.0) | 70 (20.3) | |
| Smoking status (n, %) | |||
| Never | 0 (0.0) | 29 (8.4) | <0.001 |
| Ever | 267 (100.0) | 316 (91.6) | |
| Packyears (smokers only) (mean, SD) | 48.1 (27.1) | 40.0 (27.9) | 0.001 |
| Histology (n, %) | |||
| Adenocarcinoma | 151 (56.6) | 214 (62.0) | 0.178 |
| Other NSCLCa | 101 (37.8) | 104 (30.1) | |
| Small cell | 11 (4.1) | 17 (4.9) | |
| other | 4 (1.5) | 10 (2.9) | |
a‘other NSCLC’ category includes squamous cell, adenosquamous, large cell and NSCLC not otherwise specified.