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. 2016 Feb 24;139(4):1164–1179. doi: 10.1093/brain/aww008

Figure 4.

Figure 4

Path diagram of the factors associated with the SPARE-BA index. WMH had 10.4% [95% confidence interval (CI): 8.4–12.4%] mediation of age effect on the SPARE-BA index (paths ab and dcb). CVD-RS had a 21.6% (95% CI: 17.4–25.7%) mediation of age effect on the SPARE-BA index (paths de and dcb). The common path through CVD and WMH (path dcb) shows 2.3% (95% CI: 1.3–3.3%) mediation of age effect on brain atrophy. The total mediation of age effect through WMH and CVD-RS together (path ab, dcb and de) was 28.9 (95% CI: 25.4–34.1%). The direct age effect on SPARE-BA (path f) was 70.2% (95% CI: 65.9–74.6%). All results were statistically significant ( P < 0.0001).