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. 2016 Feb 24;139(4):1164–1179. doi: 10.1093/brain/aww008

Figure 5.

Figure 5

Path diagram of the factors associated the SPARE-AD index. WMH had 32.8% (95% CI: 25.6–40.3%) mediation of age effect on the SPARE-AD index (paths ab and dcb). CVD-RS had 8.4% (95% CI: −6–23.1%) mediation of age effect on the SPARE-AD index (paths de and dcb). The common path through CVD and WMH (path dcb) shows 7.3% (95% CI: 4.4–10.8%) mediation of age effect on brain atrophy. The total mediation of age effect through WMH and CVD-RS together (path ab, dcb and de) was 34.0% (95% CI: 18.7–50.1%). The direct age effect on SPARE-AD (path f) was 66.0% (95% CI: 49.9–81.2%).