Table 1.
Demographic and clinical characteristics according to diagnostic group
| Posterior cortical atrophy | Logopenic variant PPA | Amnestic Alzheimer’s disease | Non-amnestic Alzheimer’s disease | Behavioural/dysexecutive variant Alzheimer’s disease | Corticobasal syndrome | Controls | |
|---|---|---|---|---|---|---|---|
| n | 7 | 5 | 5 | 1 | 1 | 1 | 15 |
| Age | 63 ± 10 | 65 ± 10 | 67 ± 8 | 59 | 59 | 60 | 79 ± 7a |
| Sex (male/female) | 4/3 | 1/4 | 3/2 | 1/0 | 1/0 | 0/1 | 6/9 |
| Education (years) | 15 ± 1 | 18 ± 2 | 17 ± 3 | 24 | 16 | 16 | 17 ± 1 |
| Handedness (R/L/A) | 6/1/0 | 3/2/0 | 4/0/0 (1 NA) | 1/0/0 | 0/0/1 | 1/0/0 | 14/0/1 |
| PiB status (+/−) | 7/0 | 4/0 (1 NA) | 5/0 | 1/0 | 1/0 | 1/0 | 0/15 |
| PiB global DVR | 1.86 ± 0.13 | 1.84 ± 0.38 | 1.79 ± 0.43 | 1.86 | 1.94 | 1.64 | 1.05 ± 0.03 |
| APOE ϵ4 (+/−) | 4/3 | 2/5 | 3/5 | 0/1 | 0/1 | − | 2/12 |
| CDR | 0.9 ± 0.2 | 0.6 ± 0.2 | 0.7 ± 0.3 | 0.5 | 1 | − | − |
| MMSE | 23 ± 4 | 18 ± 8 | 20 ± 5 | 27 | 21 | 16 | 29 ± 1a |
| Memory z-score | −2.5 ± 1.3 | −2.6 ± 1.5 | −3.4 ± 1.0 | −1.5 | −2.5 | − | − |
| Visuospatial z-score | −5.9 ± 2.9b | −1.9 ± 1.9 | −2.0 ± 1.4 | −0.8 | −1.4 | − | − |
| Executive z-score | −2.9 ± 2.0 | −3.7 ± 2.5 | −1.9 ± 1.9 | −0.8 | −2.4 | − | − |
| Language z-score | −2.1 ± 0.9 | −4.0 ± 1.6c | −1.7 ± 1.4 | −0.3 | −0.3 | − | − |
Differences in baseline characteristics between groups (n > 1) were assessed using ANOVA with post hoc Bonferroni tests for continuous variables and χ2 and Kruskal-Wallis with post hoc Mann-Whitney U-tests for dichotomous or categorical data.
aControls > patients, P < 0.05.
bPosterior cortical atrophy < Logopenic variant primary progressive aphasia and amnestic Alzheimer’s disease, P < 0.05.
cLogopenic variant primary progressive aphasia < posterior cortical atrophy and amnestic Alzheimer’s disease, P < 0.05.
A = ambidextrous; CDR = Clinical Dementia Rating; R = right; L = left; NA = not available.