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. 2016 Mar 28;139(5):1458–1471. doi: 10.1093/brain/aww046

Figure 4.

Figure 4

DEX but not anti-VEGFA antibody treatment decreases survival after radiotherapy. Mice with PDGF-driven gliomas were randomized into either DEX or untreated cohorts, and on the third day were further randomized into either (A) non-irradiated (No IR), (B) single dose, or (C) fractionated radiotherapy groups. DEX alone had no impact on survival, but decreased the efficacy of both single dose and fractionated radiotherapy. The cartoon at the bottom of each survival plot depicts the treatment schedule. (D) Kaplan-Meier survival curves for mice randomized into vehicle, B20-4.1.1 treatment, radiotherapy alone, or radiotherapy + B20.4.1.1 groups. Schematic illustrations of treatment paradigms for A–C are below and for D on the right together with experimental groups. P-values were calculated using a Log-rank (Mantel-Cox) test, *P < 0.05, ***P < 0.01, ****P < 0.0001.