Table 1.

Simulation results for the design in Fig. 1: the estimated means, based on 500 replicates, are reported for coefficients in model (4)

Parameter estimation
		β 12	β 22	β 23	β 32
		(first-stage interventions A 1)	(second-stage interventions for responders A 2R)	(second-stage interventions for non-responders A 2NR)	(time of intervention T 2)
True value		0.4	0.5	0.5	2
Joint Model	Estimate	0.407	0.503	0.502	1.790
	MSE	0.011	0.029	0.016	0.147
	CI%	97.8 %	95.0 %	96.8 %	94.2 %
	Length of CI	0.478	0.674	0.538	1.447
TVMEM	Estimate	0.275	0.503	0.501	4.073
	MSE	0.026	0.030	0.017	4.400
	CI%	88.0 %	95.6 %	97.0 %	0.0 %
	Length of CI	0.484	0.695	0.549	1.436

CI%: Coverage probability of the 95 % confidence interval

MSE mean squared error