Table 10.

Simulation results from the alternative simulation approach: the estimated means, based on 500 replicates, are reported for the final outcomes of the eight adaptive interventions embedded in the design

Mean of the final outcomes
	(−1,-1,-1)	(−1,-1,1)	(1,-1,-1)	(1,-1,1)	(−1,1,-1)	(−1,1,1)	(1,1,-1)	(1,1,1)
Simulated means	−0.208	−0.070	−1.589	−1.356	0.678	0.810	−0.918	−0.689
Estimated means by Joint model	−0.203	−0.066	−1.595	−1.359	0.675	0.804	−0.915	−0.683
Estimated means by TVMEM	−0.203	−0.063	−1.594	−1.363	0.672	0.804	−0.912	−0.684