Table 3.

Simulation results for the design in Fig. 1: the estimated means, based on 500 replicates, are reported for coefficients in model (4) with interactions

Parameter estimation
		β 12	β 22	β 23	β 32	β 41	β 42
		(first-stage interventions A 1)	(second-stage interventions for responders A 2R)	(second-stage interventions for non-responders A 2NR)	(time of intervention T 2)	(interaction term A 1. A 2R)	(interaction term A 1. A 2NR)
True value		−0.4	0.5	0.4	2.0	0.55	−0.40
Joint model	Estimate	−0.381	0.490	0.389	1.626	0.542	−0.397
	MSE	0.014	0.038	0.019	0.305	0.037	0.019
	CI%	97.4 %	95.6 %	96.8 %	87.0 %	96.8 %	98.0 %
	Length of CI	0.521	0.789	0.593	1.671	0.789	0.593
TVMEM	Estimate	−0.530	0.489	0.390	4.122	0.542	−0.396
	MSE	0.029	0.039	0.020	4.697	0.037	0.020
	CI%	88.2 %	95.8 %	96.4 %	0.0 %	97.0 %	97.8 %
	Length of CI	0.525	0.809	0.605	1.618	0.809	0.605

CI%: Coverage probability of the 95 % confidence interval

MSE mean squared error