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. 2016 Aug 30;16(1):112. doi: 10.1186/s12874-016-0202-7

Table 4.

Simulation results for the design in Fig. 1: the estimated means, based on 500 replicates, are reported for the final outcomes of the eight adaptive interventions embedded in the design with interactions in model (4)

Mean of the final outcomes
(−1,-1,-1) (−1,-1,1) (1,-1,-1) (1,-1,1) (−1,1,-1) (−1,1,1) (1,1,-1) (1,1,1)
Simulated means 5.456 6.306 5.009 5.000 5.400 6.249 5.577 5.565
Estimated means by Joint model 5.456 6.306 5.009 5.000 5.400 6.249 5.577 5.565
Estimated means by TVMEM 5.456 6.306 5.009 5.000 5.400 6.249 5.577 5.565