Table 7.

Simulation results for the design in Fig. 2: the estimated means, based on 500 replicates, are reported for coefficients in model (4) with interactions

Parameter estimation
		β 12	β 23	β 32	β 42
		(first-stage intervention A 1)	(second-stage interventions for responder A 2NR)	(time of intervention T 2)	(interaction termA 1 A 2NR))
True value		0.4	0.4	2.0	−0.4
Joint model	Estimate	0.408	0.422	1.784	−0.400
	MSE	0.012	0.020	0.157	0.019
	CI%	98.2 %	97.2 %	95.6 %	97.2 %
	Length of CI	0.513	0.594	1.542	0.593
TVMEM	Estimate	0.298	0.419	4.308	−0.399
	MSE	0.021	0.021	5.439	0.020
	CI%	94.8 %	97.4 %	0.0 %	97.4 %
	Length of CI	0.520	0.608	1.532	0.607

CI%: Coverage probability of the 95 % confidence interval; MSE: mean squared error