Skip to main content
. 2016 Aug 31;36(4):e00374. doi: 10.1042/BSR20160199

Figure 4. Signalling cascade activated by PDGF-BB in human PASMCs.

Figure 4

Human PASMCs were exposed to 10 ng/ml of PDGF-BB for different times as indicated. (A) Time course of PDGFRβ/ MAPK signalling by western blots with antibodies specific to phosphorylated PDGFRβ (p-PDGFRβ) and PDGFRβ, phosphorylated ERK1/2 (p-ERK1/2) and ERK1/2, phosphorylated p38MAPK (p-p38MAPK) and p38MAPK, phosphorylated JNK (p-JNK) and JNK. (B–E) Summarized results of the densitometric analyses of p-PDGFRβ (B), p-ERK1/2 (C), p-p38MAPK (D) and p-JNK (E). GAPDH was used as the loading protein. Data represent as mean ± S.E.M. (N=3). *P<0.05, **P<0.01, compared with control, ##P<0.01, compared with PDGF-BB treatment.