Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Aug 30;9(1):472. doi: 10.1186/s13071-016-1752-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 5 — Overall proinflammatory and regulatory cytokine patterns secreted by splenocytes from BALB/c mice immunized with the multicomponent LBSap vaccine, Leish-Tec® or Leishmune®. In the upper panel, the x-axis displays the index (SLcA stimulated culture/unstimulated culture) of each analyzed cytokine (IL-6, TNF-α, IL-2, IFN-γ, IL-10, IL-17A) 30 days after experimental L. infantum challenge in the different analyzed groups (n = 5 mice/group in two independent batches) (Control [□]; Leish-Tec® []; Leishmune® []; and LBSap [killed L. braziliensis vaccine plus saponin; ■]). The y-axis represents the mean values (with standard deviations) of the stimulation index of analyzed cytokines. Significant inter-group differences are marked by letters (C: Control group and LT: Leish-Tec® group). The bottom panel displays radar charts of proinflammatory and regulatory cytokines from splenocyte supernatant culture. Each axis displays the proportion of high-producing cytokines in the following groups (n = 5 mice/group in two independent batches): Control (□); Leish-Tec® (); Leishmune® (); and LBSap (killed L. braziliensis vaccine plus saponin; ■)

Inline graphic — Overall proinflammatory and regulatory cytokine patterns secreted by splenocytes from BALB/c mice immunized with the multicomponent LBSap vaccine, Leish-Tec® or Leishmune®. In the upper panel, the x-axis displays the index (SLcA stimulated culture/unstimulated culture) of each analyzed cytokine (IL-6, TNF-α, IL-2, IFN-γ, IL-10, IL-17A) 30 days after experimental L. infantum challenge in the different analyzed groups (n = 5 mice/group in two independent batches) (Control [□]; Leish-Tec® []; Leishmune® []; and LBSap [killed L. braziliensis vaccine plus saponin; ■]). The y-axis represents the mean values (with standard deviations) of the stimulation index of analyzed cytokines. Significant inter-group differences are marked by letters (C: Control group and LT: Leish-Tec® group). The bottom panel displays radar charts of proinflammatory and regulatory cytokines from splenocyte supernatant culture. Each axis displays the proportion of high-producing cytokines in the following groups (n = 5 mice/group in two independent batches): Control (□); Leish-Tec® (); Leishmune® (); and LBSap (killed L. braziliensis vaccine plus saponin; ■)