Table 3.

selection comparison: subgroup identification performance

Scenario	True # responders	Size	Sens.	Spec.	PPV	NPV	Incl.	Only
Case 1
	125.41	362.24	0.99	0.36	0.36	0.99	0.45	0.02	36.21
	125.41	227.57	0.92	0.70	0.63	0.97	0.72	0.05	35.75
	125.41	395.71	0.99	0.28	0.32	0.99	0.42	0.01	36.24
Case 2
	125.41	145.78	0.37	0.73	0.36	0.78	0.13	0.02	30.32
	125.41	237.91	0.54	0.55	0.32	0.80	0.10	0.002	30.40
	125.41	279.90	0.64	0.47	0.30	0.80	0.10	0.002	30.47
Case 3
	125.41	290.67	0.80	0.49	0.39	0.90	0.26	0.01	32.54
	125.41	245.66	0.71	0.58	0.45	0.88	0.35	0.01	32.33
	125.41	357.02	0.90	0.35	0.33	0.92	0.21	0.004	32.76
Case 4
	250.26	125.60	0.37	0.87	0.79	0.60	0.37	0.01	30.73
	250.26	243.84	0.63	0.65	0.70	0.69	0.37	0.01	30.81
	250.26	247.76	0.68	0.68	0.70	0.70	0.39	0.01	31.03
Case 5
	500	326.04	0.65	—	1.00	—	—	—	31.97
	500	246.41	0.49	—	1.00	—	—	—	31.49
	500	391.88	0.78	—	1.00	—	—	—	32.36
Case 6
	0	107.23	—	0.79	—	1.00	—	—	30.01
	0	239.91	—	0.52	—	1.00	—	—	30.01
	0	249.83	—	0.50	—	1.00	—	—	30.01

Values represent averages across 500 simulated data sets.

True responders defines as those with .

Averages based on 497 and 499 data sets in Cases 1 and 3, respectively, due to numerical problems.