Fig. 2.

PCC/precuneus-based functional connectivity patterns. (a) The resting-state functional connectivity (rs-FC) between the PCC/precuneus seed and the predefined 6-mm spherical PRN mask centered at (3, − 30, − 30) was significantly influenced by the group × session effect (b) PRN-mask-based SVC test revealed a region of the pontine nucleus which survived SVC-level FWE correction (left), and whole-brain analysis revealed a region of the postcentral gyrus which survived whole-brain-level FWE correction (right), to the group × session effect. The PRN mask and significant clusters are overlaid on a standard anatomical template (ch2bet). MNI x and y coordinates are provided below the sagittal and coronal slices. Following training, the meditation group showed an upregulation of PCC/precuneus-PRN rs-FC in the positive direction. The opposite pattern was observed for the relaxation group after training. * indicates statistically significant difference at p < 0.05. Error bars represent ± 1 standard error of the mean. Colour bar denotes t-statistics. zFC scores: r-to-z transformed functional connectivity coefficiency values (Yan and Zang, 2010).