Fig. 2.

Effects of free fatty acids on metabolism at 5.5 mmol/l glucose. Human islets were incubated at 5.5 mmol/l glucose in the presence or absence of palmitate (PA), palmitoleate (PAO), stearate (SA), or oleate (OA) for 40 min. a Representative graph of oxygen consumption rate (OCR) is shown. Rotenone and antimycin A were added as indicated by arrow. b and c OCR and extracellular acidification rate (ECAR) during 40 min were expressed as fold control. Results are means ± SEM of 4 donors. *P < 0.05 vs Control, #P < 0.05 PA vs PAO or SA vs OA