Table 1.

Reported outcomes

Studies	Reported outcomes	Follow up period	Bias grade
Brar2008	Death, MI	9.7 months	-
I-LOVE IT 2	NACCE, death, MI, stroke, TVR, TLR, ST, all bleeding, major bleeding	12 and 18 months	B
ISAR-SAFE	Primary endpoints, death, MI, ST, stroke, TIMI major and minor bleeding, BARC bleeding	9 months	B
Tarantini2016	Death, MI, composite endpoints, stent thrombosis, BARC type 3 or 5 bleeding, stroke, revascularization	1 year	-
ARCTIC	Primary endpoints, Death, MI, ST, stroke, revascularization	17 months	B
OPTIMIZE	NACCE, death, MI, stroke, ST, major bleeding, TLR, TVR, any bleeding	1 year	B
RESET	Primary endpoints, death, MI, TVR, ST, major and minor bleeding, stroke	1 year	B
EXCELLENT	Death, MI, stroke, TVR, TLR, ST, any bleeding, TIMI major bleeding	1 year	B
PEGASUS	Death, MI, stroke, TIMI major and minor bleeding	3 years	B
DAPT	ST, MACCEs, death, stroke, MI, BARC type 2,3 or 5	12 to 30 months	B
Sardella2011	Death, MI, stroke, TIMI minor bleeding, revascularization	2 years	-
PRODIGY	Death, MI, stroke, ST, TLR, TVR, TIMI major and minor bleeding, BARC bleeding	2 years	B
Thukkani2015	Death, MI, Stroke	4 years	-
ENDEAVOR	Death, MI, ST (definite and probable), stroke, major bleeding	2 years	B
ITALIC	Primary endpoints, minor bleeding, minimal bleeding, death, MI, stroke, TVR, ST, major bleeding	1 year	B

Abbreviations: MI myocardial infarction, ST stent thrombosis, TVR target vessel revascularization, TLR target lesion revascularization, NACCE net adverse clinical and cerebral events, BARC bleeding academic research consortium, TIMI thrombolysis in myocardial infarction