Table 3. Regression analysis (generalized estimating equations) of factors associated with ONSD.
| Effect | p-value (effect) | Parameter | B | 95% CI | p-value (parameter) |
|---|---|---|---|---|---|
| Intercept | <0.001 | Intercept | 8.389 | 7.530, 9.248 | <0.001 |
| Time | 0.003 | Time = baseline | −2.112 | −3.355, −0.869 | 0.001 |
| Time = 9 h | −1.237 | −1.967, −0.506 | 0.001 | ||
| Time = 24 h | 0.000 | ||||
| AMS | <0.001 | AMS = no | −0.697 | −0.897, −0.497 | <0.001 |
| Time*AMS | a | ||||
| Time*HR | 0.003 | Time = baseline*HR (bpm) | −0.004 | −0.017, 0.010 | 0.569 |
| Time = 9 h*HR (bpm) | −0.003 | −0.006, 0.001 | 0.135 | ||
| Time = 24 h*HR (bpm) | −0.017 | −0.029, −0.006 | 0.002 | ||
| ROS | a | ||||
| Time*ROS | a | ||||
| TBARS | a | ||||
| Time*TBARS | a | ||||
| TAC | a | ||||
| Time*TAC | a |
AMS, acute mountain sickness (Lake Louise score ≥3 with headache); B, estimated coefficient; CI, confidence interval; HR, heart rate; ROS, reactive oxygen species; TAC, total antioxidant capacity; TBARS, thiobarbituric acid-reactive substances.
aNot significant (parameter eliminated during the stepwise procedure).