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CaV1.2 splice variants have different affinity for clevidipine. (A and C) Currents from A) the 22-32-33 and C) 22-31-Δ33 CaV1.2 splice variants in response to a 0 mV step from a holding voltage of − 80 mV, followed by a tail voltage of − 80 mV, in the presence of the indicated concentration of clevidipine. (B and D) Average dose response (n = 4) for B) the 22-32-33 and D) 22-31-Δ33 CaV1.2 splice variants fitted with Hill equation (See Table 3 for parameters).
