Table 2.
The effects of Clopidogrel and Prasugrel on hs-CRP over 12 weeks study period.
| CLOPIDOGREL GROUP (n = 80) | PRASUGREL GROUP (n =40) | CLOPIDOGREL VERSUS PRASUGREL (WITHIN SUBGROUPS) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HS-CRP BEFORE TREATMENT (mg/dl) | P VALUE (BETWEEN SUBGROUPS) | HS-CRP AFTER TREATMENT (mg/dl) | PERCENT OF CHANGE (%) | P VALUE (BETWEEN SUBGROUPS) | HS-CRP BEFORETREATMENT (mg/dl) | P VALUE (BETWEEN |SUBGROUPS) | HS-CRP AFTER TREATMENT (mg/dl) | PERCENT OF CHANGE (%) | P VALUE (BETWEEN SUBGROUPS) | P VALUE | ||
| All | 15.10 (9.62–23.75) |
8.50 (6.00–10.75) |
39.33 (15.71–62.55) |
– | 18.00 (14.25–22.00) |
5.00 (3.00–5.00) |
72.95 (61.53–85.33) |
– | 0.002 | |||
| Gender | Male | 11.25 (8.37–19.75) |
0.03 | 8.00 (4.00–10.00) |
48.68 (21.61–62.55) |
0.18 | 18.00 (15.00–22.00) |
0.92 | 5 (3.00–5.00) |
73.68 (64.10–84.96) |
0.74 | <0.001 |
| Female | 18.00 (11.25–28.75) |
10.00 (6.00–20.00) |
33.33 (6.07–62.34) |
18.00 (12.00–23.00) |
5.00 (3.00–9.00) |
68.75 (59.09–86.36) |
<0.001 | |||||
| DM | Yes | 15.00 (9.50–21.00) |
0.91 | 11.00 (6.00–20.00) |
25.00 (4.76–33.33) |
0.007 | 15.00 (12.00–22.00) |
0.08 | 5 (3.00–5.00) |
66.66 (59.09–83.33) |
0.14 | <0.001 |
| No | 15.20 (9.25–24.25) |
8.00 (4.75–10.00) |
50.00 (21.17–64.39) |
19.00 (15.75–22.50) |
5.00 (3.00–5.00) |
73.68 (66.88–86.03) |
<0.001 | |||||
| HTN | Yes | 17.50 (11.50–24.00) |
0.01 | 10.00 (8.00–13.00) |
33.33 (20–60) |
0.77 | 15.50 (12.50–22.00) |
0.06 | 5.00 (3.00–5.00) |
67.85 (60.31–82.08) |
0.07 | <0.001 |
| No | 10.46 (6.90–23.00) |
6.00 (4.00–9.50) |
48.68 (14.28–63.40) |
19.00 (18.00–23.00) |
5.00 (3.00–5.00) |
83.33 (67.10–86.95) |
<0.001 | |||||
| Current smoking | Yes | 15.00 (9.87–25.75) |
0.72 | 9.00 (60–11.50) |
33.33 (9.58–64.39) |
0.40 | 18.00 (15.00–22.00) |
0.82 | 4.50 (3.00–5.00) |
74.34 (66.66–86.36) |
0.38 | <0.001 |
| No | 15.20 (8.00–23.00) |
8.00 (4.00–10.00) |
47.36 (25.00–58.33) |
19.00 (13.00–22.00) |
5.00 (3.00–5.00) |
70.03 (59.53–83.99) |
<0.001 | |||||
| Beta blocker | Yes | 10.20 (5.00–17.00) |
<0.001 | 6.00 (2.00–11.00) |
25.00 (4.76–50.00) |
<0.001 | 18.00 (12.50–22.00) |
0.65 | 5.00 (3.00–5.00) |
75 (61.20–83.77) |
0.90 | <0.001 |
| No | 19.00 (11.35–30.25) |
9.00 (6.00–12.00) |
55.31 (26.43–65.33) |
18.00 (15.00–22.00) |
5.00 (3.00–5.00) |
72.22 (61.53–86.36) |
<0.001 | |||||
| ACEI/ARB | Yes | 8.75 (5.00–15.00) |
<0.001 | 6.00 (2.00–10.00) |
30.55 (13.04–56.52) |
0.02 | 18.00 (15.00–22.00) |
0.79 | 4.00 (3.00–5.00) |
78.57 (66.66–85.71) |
0.68 | <0.001 |
| No | 19.00 (12.00–25.00) |
9.75 (8.00–11.00) |
50.00 (21.73–64.70) |
19.00 (12.00–22.00) |
5.00 (3.00–5.00) |
72.22 (61.20–84.84) |
<0.001 | |||||
| CCB | Yes | 9.25 (4.92–17.75) |
0.01 | 7.00 (3.00–10.00) |
32.63 (16.14–57.88) |
0.51 | 15.00 (12.00–22.00) |
0.08 | 5.00 (3.00–6.00) |
66.66 (60.42–76.83) |
0.04 | <0.001 |
| No | 17.40 (10.05–25.00) |
9.25 (6.00–16.25) |
45.58 (14.78–64.60) |
19.00 (15.42–22.00) |
4.50 (3.00–5.00) |
77.92 (66.66–86.51) |
<0.001 | |||||
| Index event | Elective | 8 (4.97–17.00) |
<0.001 | 6.00 (2.75–6.75) |
25.00 (9.58–61.17) |
0.11 | 16.25 (13.5–21.75) |
0.01 | 3.50 (3.00–5.00) |
78.40 (66.66–86.64) |
0.65 | <0.001 |
| UA | 15.10 (10.20–24.00) |
8.50 (8.00–10.00) |
44.27 (21.56–58.33) |
17 (12.00–21.50) |
5.00 (3.00–5.00) |
75.47 (59.13–85.60) |
<0.001 | |||||
| NSTEMI | 25.00 (21.00–49.50) |
18.00 (10.00–20.00 |
33.33 (24.26–63.22) |
22 (19.00–27.00) |
5.00 (3.00–9.00) |
72.22 (59.09–86.36) |
0.01 | |||||
| STEMI | 28.50 (22.00–42.50) |
10.00 (9.62–18.25) |
59.80 (51.32–66.50) |
22.00 (14.60–25.50) |
9.00 (4.00–9.00) |
67.10 (59.98–73.21) |
0.01 | |||||
| Index procedure | One-vessel | 19.00 (10.20–28.00 |
0.04 | 9.00 (6.00–10.00) |
64.28 (21.56–83.33) |
0.01 | 16.50 (13.75–22.00) |
0.36 | 5.00 (3.75–5.00) |
72.95 (65.38–79.38) |
0.60 | 0.12 |
| Multi-vessel | 15.00 (6.97–23.25) |
8.00 (5.75–14.25) |
33.33 (13.04–56.52) |
18.5 (14.65–22.25) |
4.00 (3.00–6.00) |
73.61 (60.42–86.36) |
<0.001 | |||||
| Stent | POBA | 19.00 (9.50–29.00) |
0.06 | 9.50 (3.00–10.00) |
67.24 (28–83.33) |
0.03 | 16.00 (12.00–22.00) |
0.46 | 3.00 (2.00–5.00) |
83.33 (58.33–87.50) |
0.30 | 0.07 |
| DES | 13.50 (8.50–19.75) |
8.00 (5.25–12.50) |
35.41 (13.35–56.52) |
18.00 (13.50–22.00) |
5.00 (3.25–5.00) |
67.48 (61.53–80.68) |
<0.001 | |||||
| BMS | 28.00 (9.85–40.50) |
10.00 (8.25–12.50) |
41.17 (10.69–69.04) |
19.00 (15.25–22.00) |
3.00 (3.00–5.00) |
78.57 (62.87–86.73) |
0.004 | |||||
Note: Data are shown as numbers (percentage).
Abbreviations: ACEI, angiotensin converting enzyme inhibitor; ARB, angiotensin II receptor blocker; BMS, bare metal stent; CCB, Calcium channel blocker; DES, drug-eluting stent; DM, diabetes mellitus; HTN, hypertension; NSTEMI, non-ST segment elevation myocardial infarction; POBA, plain old balloon angioplasty; STEMI, ST segment elevation myocardial infarction; UA, unstable angina.