Table 2.
Clinical and biological parameters at Emergency-Room arrival.
| Parameter | VOCs | ACSs | p | Missing |
|---|---|---|---|---|
| Number (%) | 203 (83.2) | 41 (16.8) | ||
| VOC-onset-to-hospitalization interval (h) | 22 [14–36] | 21 [14–310] | 0.55 | 11 |
| VOC night appearance | 45 (22.2) | 11 (26.8) | 0.52 | 0 |
| Temperature (°C) | 36.9 [36.5–37.2] | 36.9 [36.7–37.3] | 0.092 | 20 |
| Transcutaneous O2 saturation (%) | 99 [97–100] | 98.5 [95–100] | 0.17 | 11 |
| Breaths/min | 18 [16–20] | 20 [16–25] | 0.041 | 70 |
| Systolic blood pressure (mm Hg) | 122 [110–135] | 123 [111–135] | 0.47 | 18 |
| Diastolic blood pressure (mm Hg) | 70 [62–80] | 69 [64–78] | 0.76 | 18 |
| Arrival pain VAS (mm) | 8 [7–9] | 8 [7–10] | 0.25 | 6 |
| CPS sums for the 7 body parts | 5 [4–8] | 7 [5–12] | 0.56 | 0 |
| Spine and/or pelvis | 1 [0–2] | 2 [1–3] | < 0.001 | 3 |
| Ribs and sternum | 0 [0–1 | 0 [0–2] | 0.155 | 3 |
| Skull | 0 [0–0] | 0 [0–0] | 0.705 | 3 |
| Right upper limb | 0 [0–2] | 0 [0–1] | 0.70 | 3 |
| Left upper limb | 0 [0–2] | 0 [0–0] | 0.023 | 3 |
| Right lower limb | 1 [0–2] | 1 [0–2] | 0.94 | 3 |
| Left lower limb | 0 [0–2] | 1 [0–2] | 0.686 | 3 |
| Morphine consumption on day 1 | 42 [21–81] | 56 [30–77.5] | 0.3 | 19 |
| Red blood cells (× 1012/L) | 3.0 [2.6–3.5] | 2.7 [2.4–3.4] | 0.017 | 1 |
| Hemoglobin (g/dL) | 9.1 [8.3–9.9] | 8.2 [7.5–10.1] | 0.023 | 0 |
| White blood cells (× 109/L) | 11.3 [8.8–15.8] | 16.3 [13.3–20.1] | < 0.001 | 0 |
| Neutrophils (× 109/L) | 6.8 [5.2–10.4] | 8.6 [6.9–14.7] | 0.011 | 36 |
| Platelets (× 109/L) | 345 [280–412] | 371 [282–395] | 0.075 | 2 |
| Reticulocytes (× 109/L) | 206 [158–253] | 262 [232–343] | < 0.001 | 16 |
| Lactate dehydrogenase (IU/L) | 397 [322–526] | 501 [409–601] | 0.001 | 3 |
| Total bilirubin (μmol/L) | 36 [25–54] | 48 [33–76] | 0.005 | 3 |
| Direct bilirubin (μmol/L) | 10 [7–13] | 12 [9–17] | 0.002 | 3 |
| Indirect bilirubin (μmol/L) | 25 [17–38] | 34 [22–50 | 0.007 | 4 |
| Aspartate aminotransferase (IU/L) | 39 [29–54] | 53 [33–69] | 0.02 | 5 |
| Alanine aminotransferase (IU/L) | 23 [16–36] | 31 [16–50] | 0.17 | 3 |
| γ-Glutamyltransferase (IU/L) | 43 [24–85] | 47 [32–104] | 0.11 | 7 |
| Alkaline phosphatase (IU/L) | 77 [60–104] | 104 [80–129] | < 0.001 | 5 |
| Creatinine (μmol/L) | 59 [47–69] | 59 [47–68] | 0.81 | 2 |
| Blood urea nitrogen (mmol/L) | 2.5 [1.8–3.1] | 2.6 [2.1–3.3] | 0.20 | 2 |
| Creatine phosphokinase (IU/L) | 58 [43–91] | 67 [44–92] | 0.46 | 29 |
| C-reactive protein (mg/L) | 15 [5–42] | 35 [13–86] | 0.001 | 20 |
Bold values indicate significance at p < 0.05.
VOC, vaso-occlusive crisis; ACSs: secondary acute chest syndromes; Missing, missing data; CPS, categorical pain score.
Results are expressed as n (%), mean ± SD or median [IQR].