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. 2016 Jun 29;10:174–184. doi: 10.1016/j.ebiom.2016.06.040

Fig. 3.

Fig. 3

Effect of SR10171 and rosiglitazone on fat and metabolic parameters of DIO and lean C57BL/6 mice.

(a) Body weight change in animals fed HFD and RD for 8 weeks before initiation of feeding medicated diet for the next 4 weeks. Arrow indicates start of administration of medicated diet. Asterisks indicate significant differences between control RD and HFD + 71. (b) Body weight of lean animals at the end of an 8 week feeding medicated diet. (c) Calorimetric measurements of respiratory parameters in DIO mice at the end of experiment. Linear plots show measurements made every 20 min within 24 h period, whereas bar plots show average of measurements collected during either 12 h light or 12 h dark period. VO2 — oxygen consumption (ml/h/kg); VCO2 — carbon dioxide production (ml/h/kg); RER — respiratory exchange ratio. (d) Gene expression analysis of adipocytic markers in eWAT of DIO mice. (e) Calorimetric measurements of respiratory parameters in lean mice at the end of experiment. (f) Gene expression analysis of adipocytic markers in eWAT of lean mice. Data represent the mean ± SD (n = 4–5 per group). *P < 0.05; **P < 0.01; ***P < 0.001 One Way Anova.