Table 4.

Validation of genetic variants previously reported in invasive pneumococcal disease in the current pneumococcal meningitis cohort.

Chr	Locationa	rsb	Functionc	Gene	p-Value	OR (± 95 CI)	p-Value	OR (± 95 CI)
Case/control	Outcome
Signals of reported IPD and meningitis associations
19	48737706	rs2043211	Missense	CARD8d	0.98	1.01 (0.68–1.48)	0.09	1.65 (0.93–2.94)
1	206941864	rs3024496e	3_prime	IL-10	0.31	1.18 (0.86–1.63)	0.47	1.19 (0.74–1.91)
12	44172041	rs121908002	Stop gained	IRAK4	0.12f	–	1f	0.64 (0.07–6.19)
12	44177511	rs55944915	Missense	IRAK4	0.67	1.21 (0.50–2.92)	0.99	0.99 (0.28–3.56)
12	44180295	rs4251545	Missense	IRAK4	0.11	1.33 (0.93–1.89)	0.38	1.26 (0.76–2.08)
11	126162843	rs8177374	Missense	MAL	0.10	1.28 (0.95–1.72)	0.30	1.30 (0.86–1.98)
3	38184370	rs6853	3_prime	MYD88	0.96	1.01 (0.74–1.37)	0.93	0.98 (0.62–1.55)
4	154626317	rs5743708	Missense	TLR2	0.99	0.99 (0.62–1.62)	0.93	0.97 (0.48–1.98)
9	120475302	rs4986790	Missense	TLR4	0.47	1.16 (0.78–1.72)	0.58	1.17 (0.67–2.03)
9	120475602	rs4986791	Missense	TLR4	0.45	1.17 (0.78–1.76)	0.99	1.00 (0.56–1.79)

^aLocation is based on GRCh37/hg19.

^bVariations have been reported in Carrasco-Colom et al. (2015), Ellis et al. (2015), van Well et al. (2012) and Yuan et al. (2008).

^cThe functional consequence of the variation or region of the gene transcript it is located.

^dAdditive model p-value = 0.5.

^eSNP in linkage with the associated variation rs1800896 (upstream_gene_variant).

^fDue to low frequency and only found in cases the Fisher exact test was used.