Table 2.
Characteristics of the outcome measures
| Measure | |
|---|---|
| 10-year incidence | |
| Stroke, n (%) | 87 (3) |
| All-cause dementia, n (%) | 84 (6) |
| Alzheimer's disease, n (%) | 64 (5) |
| Vascular Dementia, n (%) | 14 (1) |
| Neuropsychological outcomes | |
| Global cognition baseline/annualized change | 0.11 (0.94) / −0.02 (0.09) |
| VRD baseline/annualized change | 8.4 (3.3) / −0.1 (0.5) |
| Similarities baseline/annualized change | 17.1 (3.4) / −0.04 (0.5) |
| Trails A baseline*/annualized change | 0.5 (0.2) / −1.1 (0.2) |
| Trails B baseline*/annualized change | 1.3 (0.9) / 0.1 (0.2) |
| LMD baseline/annualized change | 10.7 (3.5) / 0.1 (0.6) |
| MRI outcomes | |
| TBV baseline/annualized change, cm3 | 1002.6 (111.0) / −5.8 (4.2) |
| FBV baseline/annualized change, cm3 | 459.4 (59.0) / −2.9 (5.4) |
| LVV baseline/annualized change, cm3 | 21.8 (14.0) / 1.0 (0.9) |
| WMHV baseline*/annualized change | 1.0 (2.7) / 0.2 (0.4) |
FBV = frontal brain volume LMD = logical memory delayed, LVV = lateral ventricular volumes, TBV= total brain volume, MRI = magnetic resonance imaging, WMHV = white matter hyperintensity volume, VRD = visual reproductions delayed.
*
indicates that values have been log transformed, The sample sizes are 2631 for incident stroke, 1364 for incident dementia and 1597 for neuropsychology. MRI measures are available on a subset of the participants with neuropsychological measures (n=1287).