Fig. 1.

Myocardial infarction was induced by closed chest, balloon occlusion reperfusion of the LAD. Thirty-six Yorkshire swine underwent 90 min of ischemia. Twenty-four animals survived the model creation to be randomized into treatment groups. Two days post-MI swine underwent a cardiac MRI and were given either an IV infusion of porcine MSCs or a placebo. Fourteen days post-MI swine underwent a second cardiac MRI and received XFM guided transendocardial (TE) MSC injections or placebo injections. The study design resulted in four treatment groups: IV placebo plus TE placebo (−−) (n=6), IV placebo plus TE MSC (−+) (n=6), IV MSC plus TE placebo (+−) (n=6), and IV MSC plus TE MSC (++) n=6). Swine were survived out to 55 days post-MI at which time a follow-up cardiac MRI and invasive pressure-volume loop analysis was carried out prior to necropsy